Our results show that PE_PGRS38 substantially downregulated TLR4, p-IKB-α, Myd88, p-NF-κB, and NF-κB in normal and LPS-treated RAW26.7 macrophages during infection, while expression of IKB-α upregulated, as shown in Figure 4 and Figure S4. The gene discussed is TLR4; the disease is infection.