Dysregulated chemokine signaling alters the chemotactic recruitment of both anti-tumor and protumor cells, including the suppression of T cell-recruiting chemokines/receptors like CXCL9, CXCL10, CXCL11, CXCL13, CX3CL1, and CCL2, which can be epigenetically regulated or involve pathways that increase CXCL8-CXCR1/2 signaling, recruiting MDSCs and neutrophils to the TME [438]. Here, CCL2 is linked to neoplasm.