The immunoregulatory functions of MDSCs have been delineated in murine models across various cancer types, including the induction of de novo generation of FoxP3+ Treg cells, the polarization of macrophages towards an immunosuppressive M2 phenotype, and the production of ROS to inhibit IFN-γ secretion and proliferation of antigen-specific CD8+ T cells [231,232]. Here, CD8A is linked to cancer.