NFKB1 and type 2 diabetes mellitus: Recent studies have identified circulating miRNAs altered by metformin treatment in T2DM patients, with miR-194-5p and miR-148-3a being of special interest due to their impact on Wingless-type mouse mammary tumor virus (MMTV) integration site family (Wnt) and Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) signaling pathways, both involved in T2DM development [85].