TP53 and neoplasm: In humans, it has been discussed that the LT-ag of SV40 and JCPyV can bind various proteins such as transcription factors, DNA repair and replication enzymes, tumor suppressors, anti-apoptotic proteins, signaling proteins and other proteins involved in the architecture of the cytoskeleton and intracellular trafficking -p53 and retinoblastoma protein, [147]; however, on the other hand, according to Hodgkin’s lymphoma, it was stated in previous sections that LT-ag bind tumor suppressors, meaning that the supposed JCPyV can act as a tumor suppressor.