TARDBP and amyotrophic lateral sclerosis: There are several genes that contribute to developed ALS, such as superoxide dismutase (SOD1), fused in sarcoma (FUS), chromosome 9 open-reading frame 72 (C9Orf72), and transactive response DNA-binding protein 43 (TDP-43), found in different percentages across family and sporadic cases in ALS patients [3,4,5,6].