A meta-analysis study found the possibility of increased levels of ferritin, CK, the transferrin saturation coefficient (TSC), and fasting blood glucose (FBG), as well as a decrease in the level of TIBC, in ALS cases in comparison with a control [53]; this may indicate that ALS diseases have multifactorial causes with degeneration of motor neuron activation. This evidence concerns the gene TF and amyotrophic lateral sclerosis.