The PI3K/AKT/mTOR signaling pathway has cross-talk with the Ras/Raf/MAPK (MEK)/ERK pathway and tumor suppressor gene pathway: PI3K, a family of lipid kinases and class IA PI3Ks, which comprises a catalytic p110 subunit and a regulatory p85 subunit. This evidence concerns the gene AKT1 and neoplasm.