Furthermore, CHAC1 was among the most upregulated genes in SCC and glioblastoma cells (>16 and 25-fold, respectively) following treatment with PAM [209,210] that was sizably larger than in keratinocytes [171], indicating an intense degree of redox stress aggravating the UPR in cancer cells that led to apoptosis [209]. The gene discussed is CHAC1; the disease is cancer.