This was supported by other studies comparing HaCaT to melanoma cell lines and human brain cancer (U87) cells to normal astrocytes, showing that direct CP selectively killed cancerous, but not healthy cells by intracellular ROS inducing autophagy or p38- or JNK-dependent caspase 3-driven apoptosis [26,226,232,274]. Here, MAPK8 is linked to melanoma.