Nevertheless, the implication of phosphorus-containing compounds in cytotoxic activity related to the anti-neoplastic potential of osteosarcoma was investigated a long time ago by Naviglio et al. who revealed that human osteosarcoma U2OS cell cultures manifested cell cycle inhibition with downregulation of cAMP and adenylate cyclase when exposed to inorganic phosphate [23]. The gene discussed is ADCY1; the disease is osteosarcoma.