BID and osteosarcoma: In addition, modulation of the apoptotic pathway by the P4 sample (Figure 9) corroborates the above-mentioned aspects by revealing important downregulation of Bid; this is indicative of the possible anti-neoplastic activity of this phosphorus-containing compound in SAOS-2 cells, as it disrupts the balance between pro-apoptotic and anti-apoptotic signals in SAOS-2 osteosarcoma cells, a phenomenon that is responsible for reducing cancer cell sensitivity to apoptotic signals, thus making the cells more resistant to treatment-induced cell death and promoting tumor survival.