However, Mizerska-Kowalska et al. [3] continued the study beyond the in silico evaluation by testing the organophosphorus compounds (derivatives of two genetically different osteosarcoma cell cultures: (i) HOS cells characterized by high tumorigenicity, invasion and migration activity and (ii) SAOS-2 cells that present medium tumorigenic potential, invasion and proliferation [38]), thus observing an anti-proliferative capacity, especially on HOS osteosarcoma cells, with the compounds acting as neutral endopeptidase inhibitor agents [3]. This evidence concerns the gene MME and osteosarcoma.