An investigation into single nucleotide polymorphisms (SNPs) within NLRP1, NLRP3, NLRC4, CARD8, CASP1, and IL1B genes revealed a significant association between two SNPs residing in NLRP3 and IL1B with increased susceptibility to HIV-1 infection [103,104]. This evidence concerns the gene NLRP1 and HIV-1 infection.