BRCA1 and familial pancreatic carcinoma: Carriers of BRCA1 mutations have an estimated lifetime risk of developing breast cancer of 55–72%, a 39–44% risk of developing ovarian cancer, a 21–29% risk for males of developing prostate cancer, and a 1–2% risk for males of developing breast cancer, as well as a 1–3% chance of developing pancreatic cancer.