BRCA1 and breast carcinoma: Carriers of BRCA2 mutations have a 45–69% risk of developing breast cancer, an 11–17% risk of developing ovarian cancer, and a 27–60% risk for males of developing prostate cancer, as well as a higher BRCA1 risk of 6–8% for males of developing breast cancer and a 3–5% risk of developing pancreatic cancer [10,16,17].