Another crucial junction between IFN-I dysregulation and Alzheimer’s disease pathobiology occurs via the second messenger cyclic GMP–AMP (cGAS)-cyclic GMP–AMP receptor stimulator of interferon genes (STING) (cGAS-STING) pathway directly, which upregulates IFN-I signaling as a response to the detection of cytosolic DNA [12]. This evidence concerns the gene STING1 and early-onset autosomal dominant Alzheimer disease.