Scrutinizing the Agora resource, we determined that 9 out of 14 genes had a target risk score >2.5 and were significantly differentially expressed in AD vs. control comparisons, namely HLA-C (4.74), HLA-B (4.68), HLA-A (4.33), PSMB8 (4.05), IFITM3 (3.42), HLA-E (3.17), IFITM1 (3.08), OAS2 (2.92) and MX1 (2.6). The gene discussed is HLA-E; the disease is Alzheimer disease.