In AD pathology, it is well established that microglia are involved in the progression of neurodegeneration by shifting to a cytotoxic and proinflammatory phenotype; however, early in disease onset, microglia have been observed to support brain health and neuroprotection by migrating to areas of the brain with tau and amyloid aggregates and initiating their phagocytosis and clearance [54]. This evidence concerns the gene MAPT and Alzheimer disease.