Moreover, in HCAEC endothelial cells, the EDEM1 mRNA—an ER stress-induced factor that disposes of misfolded proteins—was upregulated 24 and 48 h following infection, but not in Grp78, CHOP, and ATF4, indicating differences regarding the ER stress response mechanism during the virus infection [93]. This evidence concerns the gene HSPA5 and infection.