Counterintuitively, however, we found that, rather than increasing TG2 expression, the development of chemoresistance to cisplatin in hepatocellular carcinoma cells was accompanied by a marginal decline in the levels of total TG2 mRNA and protein, compared to parental cells (Figure 2B), though the TG2 enzymatic activity was relatively unaffected and may even have slightly increased (Figure 2C). This evidence concerns the gene TGM2 and hepatocellular carcinoma.