Gornowicz et al. proved that patients with high dental caries activity (DMF > 11) had significantly increased levels of secretory IgA, histatin-5, and lactoperoxidase (LPO) compared to subjects with lower caries activity (p < 0.05) [20] Conversely, Nireeksha et al. reported that salivary IgA (sIgA) levels in subjects with active caries were decreased with respect to caries-free subjects (p < 0.05) [23]. Here, HTN3 is linked to dental caries.