The Hutchinson–Gilford progeria syndrome (HGPS or progeria) is caused by a mis-splicing dominant-negative mutation (G608G; c.1824 C>T) in LMNA, generating toxic progerin, which is responsible for accelerated aging and limits the lifespan of children to approximately 14 years [121]. This evidence concerns the gene LMNA and Hutchinson-Gilford progeria syndrome.