SPARC and osteogenesis imperfecta: In addition to collagen, a number of genes are also involved in the pathogenesis of OI: BMP1, CCDC134, CREB3L1, CRTAP, FKBP10, IFITM5, KDELR2, MBTPS2, MESD, P3H1, P4HB, PLOD2, PPIB, SEC24D, SERPINF1, SERPINH1, SP7, SPARC, TENT5A, TMEM38B, and WNT1 [30,31,32].