Regarding the molecular mechanisms involving MISP signaling in cancer, particularly in the context of pancreatic cancer, research indicates that the depletion of MISP leads to an increase in the accumulation ofthe IQ Motif Containing GTPase Activating Protein 1 (IQGAP1) at the cell cortex, concomitant with a reduction in active Cell Division Cycle 42 (Cdc42) levels. The gene discussed is MISP; the disease is pancreatic neoplasm.