This discovery implies that MISP might contribute as a potential risk factor for CRC through its interaction with Opa Interacting Protein 5 (OIP5), forming a complex which triggers the activation of the JAK2-STAT3 (Janus kinase 2-Signal transducer and activator of transcription 3) signaling pathway [25]. This evidence concerns the gene JAK2 and colorectal carcinoma.