A 72-year-old male with kappa light chain-restricted MM, with high-risk cytogenetics, including TP53 deletion and past medical history notable for spastic paraplegia secondary to cord compression at the T6 level caused by progressive MM, presented with fever, altered mental status (AMS), and new-onset right upper and lower extremity (RUE) paresis amidst a COVID-19 infection. This evidence concerns the gene TP53 and Miyoshi myopathy.