NF1 and plexiform neurofibroma: Hence, this genetic alteration in NF1 predisposes afflicted individuals to diverse tumors, such as benign nerve sheath tumors or neurofibromas, malignant peripheral nerve sheath tumors (MPNST) or neurofibrosarcomas, brain tumors, spinal cord tumors, and optic gliomas, as well as additional complications including intellectual disabilities and bone deformities [1].