Specifically, the presence of DNMT3A R882 mutations in MDS is correlated with leukopenia and associated with mutations in SRSF2 and IDH2, with characteristics such as an excess of blasts and an elevated likelihood of transforming into AML, particularly when compared with cases lacking DNMT3A R882 mutations [41]. This evidence concerns the gene DNMT3A and Decreased total leukocyte count.