The other genetic mutation that plays a role in the pathogenesis of MDS with 5q is the casein kinase 1A1 gene (CSNK1A1), located in the common deleted region of 5q, and having a somatic mutation in CSNK1A1 on the non-deleted allele leads to haploinsufficiency and clonal dominance through the deregulated WNT/beta-catenin pathway [10]. This evidence concerns the gene CSNK1A1 and myelodysplastic syndrome.