Specifically, the presence of DNMT3A R882 mutations in MDS is correlated with leukopenia and associated with mutations in SRSF2 and IDH2, with characteristics such as an excess of blasts and an elevated likelihood of transforming into AML, particularly when compared with cases lacking DNMT3A R882 mutations [41]. The gene discussed is DNMT3A; the disease is myelodysplastic syndrome.