EDNRB and cancer: Furthermore, triple co-cultures including fibrocytes, cancer cells and macrophages not only enhanced pro-proliferative and pro-migratory markers of cancer cells, shifted the macrophages toward a M2-like phenotype and increased phenotypic maturation markers in fibrocytes, but also an up-regulation of both ETA and ETB was detected in the separated cell fractions correlating with increased expression of both endothelins in human and mouse lung cancer samples [75].