At the same time, some efforts are needed to address the potential threats from longstanding diabetes including possible brain damage and Alzheimer’s disease-related neurodegeneration.7 In a recent publication, an automated insulin delivery (AID) system was shown to increase specifically TITR, when settings were adjusted to the target of 5.5 mmol/L (100 mg/dL) and 2 hours of active insulin with the MiniMed 780G system (Medtronic, Northridge, CA, USA).8 This evidence concerns the gene INS and diabetes mellitus.