Additionally, mild hyperthermia ACFDG‐assisted ROS scavenging blocks the activation of the NF‐κB signaling pathway in the diabetic periodontal inflammatory microenvironment, which can specifically repair dysfunctional mitochondria, thus ending the vicious bone microcirculation induced by diabetes‐induced hyperglycemia and bone loss. This evidence concerns the gene NFKB1 and diabetes mellitus.