TREM2 and autoimmune disease: Myeloid leukocytes are indispensable in autoimmune diseases due to their roles in antigen processing and presentation, regulation of inflammatory responses, and secretion of cytokines.[20] Here, we subclustered myeloid cells (N = 3677) as M2‐like macrophages, intermediate macrophages without apparent M1 or M2 polarization, TREM2+ lipid‐associated macrophages, proliferating macrophages, CD14+ classical monocytes, CD16+ nonclassical monocytes, type 2 conventional dendritic cells (cDC2), NEs, and mast cells (Figure 5A; Figure S6A–D, Supporting Information).