In a murine study of TBI using both controlled cortical impact (CCI) and diffuse closed head injury (CHI) models, plasma thrombin generation and EV-TF was increased at 6 and 24 h after injury in the CCI model and at 6 h in the CHI model suggesting that TF is implicated in the hypercoagulability seen after TBI. This evidence concerns the gene TF and thrombophilia.