HTR5A and migraine disorder: In 22 years, Yang et al. (61) showed that in a rat model of nitroglycerin (NTG)-induced migraine, the Chinese herbal formula Xiongshao Zhitongfang (XZR) regulated NO, 5-HT, CGRP, and SP to normal levels, while inhibiting mast cell degranulation and the release of inflammatory factors, which resulted in attenuation of migraine symptoms.