ADA and viral infectious disease: Relatedly, previous studies have shown that Spt–Ada–Gcn5 acetyltransferase (SAGA), a universal transcriptional coactivator, upregulates CpDcl2 upon hypovirus infection, and knockout of SAGA subunits Gcn5, Sgf73, and Ada2 abolished any induction of CpDcl2 transcription upon viral infection (Andika et al., 2017, 2019).