Based on our current results, the change of excitability observed in sensory neurons in neuropathic pain may not be due solely to a change in maximum conductance as most previous studies suggest (Rogers et al., 2006; Hameed, 2019), but can be dominated by a left shift (hyperpolarized) in the steady state of activation of Nav1.8. The gene discussed is SCN10A; the disease is neuropathic pain.