In retrospect, a more appropriate mesothelioma mouse model for chemoprevention or interception studies would have a germline mutation in only a single tumor suppressor gene, e.g., asbestos-exposed Nf2+/− or Bap1+/− mice, which develop mesothelioma after a longer time frame than Nf2+/−;Cdkn2a+/− animals. The gene discussed is CDKN2A; the disease is mesothelioma.