HMGB1 and mesothelioma: Mesothelioma carcinogenesis has been proposed to be associated with asbestos-induced mesothelial cell necrosis that leads to the release of high-mobility group protein B1 (HMGB1), a mediator of inflammation that activates the NLRP3 inflammasome and subsequent IL-1β secretion, as well as macrophage accumulation and the release of TNF-α, which increases the survival of asbestos-damaged mesothelial cells [4].