In advanced AD stages, the depletion of cholinergic neurons leads to a 90% reduction in AChE levels, while BChE levels and activity elevate to 165% of normal levels, overtaking the main responsibility for the termination of cholinergic neurotransmission.45–47 These pathological changes are observed primarily in the hippocampus, a region intricately related to cognitive and memory functions. This evidence concerns the gene BCHE and Alzheimer disease.