MAPT and Alzheimer disease: The detrimental effects of acrolein encompass DNA damage, disruption of mitochondrial function, initiation of endoplasmic reticulum stress, protein adduction, promotion of inflammation, impairment of cell membranes, formation of reactive oxygen species (ROS), and tau phosphorylation, thereby influencing the pathophysiology of AD (Dang et al., 2010; Moghe et al., 2015).