ACLY and hepatocellular carcinoma: For example, Ning et al. (2022) found that USP22 is a key factor in fatty acid synthesis, and it can stabilize peroxisome proliferator-activated receptor γ (PPARγ) through deubiquitination, thereby upregulating the expression of acetyl-CoA carboxylase (ACC) and ATP citrate lyase (ACLY) to promote hepatocellular carcinoma growth.