Proteins such as interferon-γ (IFN-γ)87, tumor necrosis factor-alpha (TNF-α)88, anti-cyclic citrullinated peptide antibody (anti-CCP)89, and eosinophilic cationic protein (ECP)90 are biomarkers of inflammatory diseases such as autoimmune hepatitis, rheumatoid arthritis (RA), and allergic rhinitis (AR) and are used for diagnosis. This evidence concerns the gene RNASE3 and rheumatoid arthritis.