Leukocytosis, anemia, elevated CRP, fibrinogen and D-dimer, and hypoalbuminemia were found. TTE showed aortic stenosis and aortic regurgitation with suspected paravalvular abscess. Mild mitral regurgitation, atrial fibrillation, and small pericardial effusion were noted. Blood cultures positive for G. sanguinis. The gene discussed is CRP; the disease is Increased total leukocyte count.