The seven KEGG pathways with considerable enrichment were dopaminergic synapse (p = 7.94*10−7), the neuroactive ligand–receptor interaction (p = 4.47*10−5), the renin-angiotensin system (p = 7.41*10−5), central carbon metabolism in cancer (p = 7.08*10−4), the synaptic vesicle cycle (p = 8.71*10−4), chemical carcinogenesis-receptor activation (p = 6.17*10−3), and the calcium signaling pathway (p = 7.94*10−3), suggesting that AMS can regulate metabolic pathways related to sleep and restore the function of metabolic pathways that were impacted by insomnia (Figure 4). This evidence concerns the gene REN and ablepharon macrostomia syndrome.