GPT and Thrombocytopenia: In patients with consistently normal serum alanine aminotransferase (ALT) levels but HBV DNA levels above 2000 IU/ml, performing liver biopsy is indicated if the patient is over 30 years old or if the patient is under 30 years old and has a suspected liver injury (prolonged prothrombin time, low albumin, thrombocytopenia).