For example, the cholesterol transporter ATP-binding cassette transporter A1 (ABCA1) gene variant (R230C, rs9282541) is unique to Native American individuals and has been associated with low high-density lipoprotein cholesterol (HDL-C) levels, obesity and type 2 diabetes in admixed Mexicans (51, 52). This evidence concerns the gene ABCA1 and obesity due to melanocortin 4 receptor deficiency.