CBD has previously been found to attenuate social deficits in Scn1a +/− mice, which is a mono-genetic mouse model of Dravet syndrome that exhibits autism-like behaviors (Kaplan et al., 2017; Patra et al., 2020). Here, SCN1A is linked to encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.