SCN1A and Anxiety: Kaplan et al. (2017) demonstrated in the Scn1a +/− mouse model of Dravet syndrome that the autism-like social impairments seen in the three-chamber sociability test were improved following acute I.P. injection of CBD at doses of 10 mg/kg and 20 mg/kg. CBD was also able to attenuate seizures at high doses (100 mg/kg and 200 mg/kg) (Kaplan et al., 2017). More recently, Patra et al. (2020) found that twice daily subcutaneous 100 mg/kg CBD injections administered chronically for 4 weeks improved sociability and anxiety-like behavior in this same Scn1a +/− mouse model.