The origin of WMLs in migraine is supposed to be a microvascular ischemic pathomechanism due to attack-related oligemia and focal hypoperfusion (Kruit et al., 2006; Dodick and Roarke, 2008; Ersoy et al., 2020), while MS lesions are the result of the blood–brain barrier disruption due to a complex mixture of primary degenerative processes, involvement of innate immunity, CD4+, CD8+ T cells, and B cells (Rahmanzadeh et al., 2018). The gene discussed is CD4; the disease is migraine disorder.