HTR5A and Anxiety: On the contrary, the activation of 5-HT released by the DRN-BNST pathway in a highly anxious environment will cause hyperpolarization of BNST neurons, but this inhibitory effect can be blocked by 5-HT1A receptor antagonists (Garcia-Garcia et al., 2017), indicating that the activation of BNST neurons expressing 5-HT1A receptors has an anti-anxiety effect.