When the release of 5-HT in BNST is relatively low, the knockdown effect of 5-HT1A may not appear under low stress conditions, and it is also possible that the postsynaptic 5-HT1A receptor is expressed in the anxiety and anti-anxiety circuits of BNST at the same time, and their removal has a net neutral effect on anxiety-like behavior (Mazzone et al., 2018). Here, HTR5A is linked to Anxiety.