CHEK2 and cancer: Pathogenic variants of ATM (ataxia-telangiectasia mutated), CHEK2 (checkpoint kinase 2), PALB2 (partner and localizer of BRCA2), and XRCC2 (X-ray repair cross-complementing 2) tumor suppressor genes (TSGs) have been associated with the development of cancers (Moslemi et al., 2021).