AKT1 and diabetes mellitus: GO and KEGG enrichment analysis of the 67 genes showed that the main pathways related to diabetes were extracellular matrix (ECM), protein digestion and absorption, PI3K-Akt signaling pathway, calcium signaling pathway, MAPK signaling pathway and AGE-RAGE signaling pathway in diabetic complications, etc. (Figures 7D, E and Supplementary Table S6), ECM have the closest relationship with VIDD in diabetic mice.