Reducing O-GlcNAcylation of nNOS was neuroprotective by shielding neurons from apoptosis and decreasing neuronal death during glutamate stimulation by reducing the formation of the nNOS-post-synaptic density protein 95 complex, indicating a potential novel therapeutic approach for treating ischemic stroke (Chen et al., 2017). Here, NOS1 is linked to ischemic stroke.