These factors comprise age, high blood pressure, atrial fibrillation, diabetes on insulin, critical state, LVEF, estimated eGFR, P2Y12 inhibitor use, endocarditis, number of procedures, only valvular surgery, only CABG surgery, length of CPB time, norepinephrine use, and intraoperative blood transfusion. This evidence concerns the gene INS and endocarditis.