These factors comprise age, high blood pressure, atrial fibrillation, diabetes on insulin, critical state, LVEF, estimated eGFR, P2Y12 inhibitor use, endocarditis, number of procedures, only valvular surgery, only CABG surgery, length of CPB time, norepinephrine use, and intraoperative blood transfusion. The gene discussed is INS; the disease is hypertensive disorder.