The study revealed that Jianpi Jiedu Recipe effectively inhibits colorectal cancer metastasis by suppressing the extracellular vesicle-mediated expression of ITGBL1, inhibiting the TNFAIP3-NF-kB pathway activity, and subsequently reducing the activation of CAFs (Li R et al., 2022). The gene discussed is ITGBL1; the disease is colorectal cancer.