PPARGC1A and Alzheimer disease: Furthermore, studies have shown that other flavonoids, including dihydromyricetin (Liu et al., 2018), fisetin (Yang W. et al., 2019), icariside II (Yin et al., 2018), curcumin (Li et al., 2015), and genistein (Valles et al., 2010; Bonet-Costa et al., 2016) may also have potential benefits for AD by regulating the AMPK/PGC-1α pathway (Micek et al., 2022).