ex Nees (Acanthaceae; Andrographis herba), in nude mice bearing breast cancer xenografts with MCF-7 cells (ip, 150 mg/kg/day, 16 days), can hinders Estrogen Receptor 1 transcription by targeting the ROS-FOXM1 axis and indirectly curtails the Wnt/β-catenin signaling pathway, thus stalling breast cancer cell proliferation (Xu et al., 2022). This evidence concerns the gene ESR1 and breast carcinoma.