AKT1 and breast cancer: Underw (Trametes robiniophila murr), in female mice bearing breast cancer xenografts with MCF-7 cells (ig, 100 μL solution containing 50 mg, 40 days), inhibit the Wnt/β-catenin signaling pathway by targeting the AKT/mTOR pathway, leading to cell cycle blockade at the G0/G1 phase, and triggering autophagy-induced apoptosis.