SLCO2A1 and primary hypertrophic osteoarthropathy: Defective PGT due to loss-of function (LOF) mutations elevates extracellular PGE2 levels and are consequently linked to inflammatory diseases such as Primary Hypertrophic Osteoarthropathy (PHO) and Chronic Enteropathy Associated with SLCO2A1 (CEAS) (Diggle et al., 2012; Umeno et al., 2015; Umeno et al., 2021).