To this end, HEK-JumpIn-SLCO2A1 cells were generated that expressed either PHO mutant L563P, thiazide-induced hyponatremia (TIH) mutant A396T or A396E, i.e., a phospho-mimic of A396T that was reported to have decreased uptake activity). Here, SLCO2A1 is linked to Hyponatremia.