On top of that, T mutant allele of CD44 (rs8193C>T) could trigger PKC–Twist, PKC–Nanog, and Nanog–Stat signaling pathways through binding to PUM 2, which is related to prediction of prostate neoplasms and prognosis factor in prostate neoplasms.230. The gene discussed is NANOG; the disease is prostate neoplasm.